Carcinogenicity and chronic toxicity in mice and rats administered vinyl acetate monomer in drinking water.

@article{Umeda2004CarcinogenicityAC,
  title={Carcinogenicity and chronic toxicity in mice and rats administered vinyl acetate monomer in drinking water.},
  author={Yumi Umeda and Michiharu Matsumoto and Kazunori Yamazaki and Makoto Ohnishi and Heihachiro Arito and Kasuke Nagano and Seigo Yamamoto and T. Matsushima},
  journal={Journal of occupational health},
  year={2004},
  volume={46 2},
  pages={87-99}
}
Carcinogenicity and chronic toxicity of vinyl acetate monomer (VA) were examined in male and female Crj:BDF1 mice and F344/DuCrj Rats. Groups of 50 mice and 50 rats of each sex were orally administered VA in drinking water containing 0, 400, 2,000 or 10,000 ppm (g/g) VA for 104 wk. Squamous cell tumors were clearly evident in the upper digestive tract of treated mice and rats, and in the larynx of treated mice of both sexes. In mice, squamous cell carcinomas and papillomas were observed in the… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 30 references

A comparative study , with 40 chemicals , of the efficiency of the Salmonella assay and the SOS Chromotest ( kit procedure )

  • JP Buchet A Brams, MC Crutzen-Fayt, C De Meester, R Lauwerys, A Leonard
  • Ann NY Acad Sci
  • 2002

Four - week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium

  • NL Gladnick MS Bogdanffy, T Kegelman
  • Inhal Toxicol
  • 2002

Kegelman and SR Frame: Four-week inhalation cell proliferation study of the effects of vinyl acetate on rat nasal epithelium

  • MS Bogdanffy, T NL Gladnick
  • Inhal Toxicol
  • 1997

and ME Andersen : Mode - of - action - based dosimeters for interspecies extrapolation of vinyl acetate inhalation risk

  • DR Plowchalk MS Bogdanffy, R Sarangapani, TB Starr
  • Inhal Toxicol
  • 1997

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