Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals.

@article{Hirakawa2003CarcinogenicSI,
  title={Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals.},
  author={Kazutaka Hirakawa and Kaoru Midorikawa and S Oikawa and Shosuke Kawanishi},
  journal={Mutation research},
  year={2003},
  volume={536 1-2},
  pages={91-101}
}
Semicarbazide, a hydrazine derivative, is carcinogenic to mice but shows no or little mutagenicity in the Salmonella-microsome test. To clarify whether or not the genotoxic mechanism contributes to the non-mutagenic carcinogenicity of semicarbazide, we investigated DNA damage induced by semicarbazide using 32P-5'-end-labeled DNA fragments obtained from the… CONTINUE READING