Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium‐term multi‐organ bioassay

@article{Inoue2009CarcinogenicPO,
  title={Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium‐term multi‐organ bioassay},
  author={K. Inoue and M. Yoshida and M. Takahashi and H. Fujimoto and M. Shibutani and M. Hirose and A. Nishikawa},
  journal={Cancer Science},
  year={2009},
  volume={100}
}
  • K. Inoue, M. Yoshida, +4 authors A. Nishikawa
  • Published 2009
  • Biology, Medicine
  • Cancer Science
  • Madder color (MC), a food coloring extracted from roots of Rubia tinctorum L., has been proven to exert carcinogenicity in the rat kidney and liver. Furthermore, it induces DNA adducts in the kidney, liver, and colon. MC is in fact composed of anthraquinones such as lucidin‐3‐O‐primeveroside and alizarin. To clarify which of these might be responsible for the carcinogenicity, a rat medium‐term multi‐organ carcinogenesis bioassay was performed focusing on the kidney, liver, and colon. Male 6… CONTINUE READING
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    References

    SHOWING 1-10 OF 30 REFERENCES
    Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study.
    • K. Inoue, M. Yoshida, +4 authors A. Nishikawa
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2009
    • 25
    Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats.
    • K. Inoue, M. Yoshida, +6 authors A. Nishikawa
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2009
    • 12
    One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver.
    • K. Inoue, M. Shibutani, +6 authors A. Nishikawa
    • Medicine, Biology
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2008
    • 8
    A 13-week subchronic toxicity study of madder color in F344 rats.
    • K. Inoue, M. Shibutani, +5 authors M. Hirose
    • Biology, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2008
    • 17