Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism

Abstract

The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation of three polycyclic aromatic hydrocarbons (PAHs) in a panel of isogenic colorectal HCT116 cells with differing TP53 status. Cells that… (More)
DOI: 10.1007/s00204-014-1409-1

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Cite this paper

@inproceedings{Wohak2014CarcinogenicPA, title={Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism}, author={Laura E. Wohak and Annette M. Krais and Jill E Kucab and Julia Stertmann and Steinar \Ovreb\o and Albrecht Seidel and David H. Phillips and Volker M Arlt}, booktitle={Archives of Toxicology}, year={2014} }