Carcinogenic polycyclic aromatic hydrocarbon‐DNA adducts and mechanism of action

@article{Baird2005CarcinogenicPA,
  title={Carcinogenic polycyclic aromatic hydrocarbon‐DNA adducts and mechanism of action},
  author={W. Baird and L. A. Hooven and B. Mahadevan},
  journal={Environmental and Molecular Mutagenesis},
  year={2005},
  volume={45}
}
Polycyclic aromatic hydrocarbons (PAHs) are a class of widespread environmental carcinogens. Most of our knowledge of their mechanisms of metabolic activation to DNA‐binding “ultimate carcinogenic” metabolites has come from analysis of the DNA interaction products formed by these highly reactive intermediates. Studies of their role in forming DNA‐binding intermediates identical to those formed in vivo from the PAH itself have also allowed identification of the particular cytochrome P450 enzymes… Expand
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