Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes.

  title={Carcinogenic metal induced sites of reactive oxygen species formation in hepatocytes.},
  author={Jalal Pourahmad and Peter James O'Brien and Farzaneh Jokar and Bahram Daraei},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  volume={17 5-6},
Severe chronic liver disease results from the hepatic accumulation of copper nickel, cobalt or iron in humans and on the other hand cadmium, dichromate and arsenic may induce lung or kidney cancer. Acute or chronic CdCl2, HgCl2 or dichromate administration induces hepatic and nephrotoxicity in rodents. Oxidative stress is often cited as a possible cause but has not yet been measured. For the first time we have measured the reactive oxygen species (ROS) formation induced when cells are incubated… CONTINUE READING
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Hepatocyte lysis

  • J. Pourahmad, A. Mihajlovic, P. J. O’Brien
  • 2001
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