Carcinogenic effect of subcutaneously administered N-nitroso-2,6-dimethylmorpholine in Syrian golden hamsters.

@article{Althoff1978CarcinogenicEO,
  title={Carcinogenic effect of subcutaneously administered N-nitroso-2,6-dimethylmorpholine in Syrian golden hamsters.},
  author={J. Althoff and C. Grandjean and B. Gold},
  journal={Journal of the National Cancer Institute},
  year={1978},
  volume={60 1},
  pages={
          197-9
        }
}
  • J. Althoff, C. Grandjean, B. Gold
  • Published 1978
  • Medicine
  • Journal of the National Cancer Institute
  • N-Nitroso-2,6-dimethylmorpholine (DMNM) was examined in Syrian golden hamsters in a comparative study of N-N-dipropylnitrosamine (DPN) metabolites. DMNM was administered sc, and the results were compared with those of a previous study in which the compound was given intragastrically. DMNM was more toxic when administered sc, and the respiratory tract was the main target organ (with a 100% tumor incidence). With an sc administration, neoplasms occurred earlier in the hamsters than with an… CONTINUE READING
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