Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine

  title={Carcinogenic Action of N-Methyl-N′-nitro-N-nitrosoguanidine},
  author={Takashi Sugimura and Minako Nagao and YOSHIKIYO OKADA},
N-Methyl-N′-nitro-N-nitrosoguanidine (NG) is known to be a potent mutagenic substance for Escherichia coli1, Salmonella typhimurium2, and Chlamydomonas reinhardi3. Induction of chromosomal aberrations in the cells of root meristems of Vicia faba by NG has been reported4. It is claimed that NG is the most potent mutagen yet discovered, since NG induced at least one mutation per cell of Escherichia coli treated at the optimal condition permitting 50 per cent survival5. The production of a number… CONTINUE READING