Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.

Abstract

DNA mismatch repair (MMR) deficiency results in a strong mutator phenotype and high-frequency microsatellite instability (MSI-H), which are the hallmarks of tumors arising within Lynch syndrome. MSI-H is characterized by length alterations within simple repeated sequences, microsatellites. Lynch syndrome is primarily due to germline mutations in one of the… (More)

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@article{Imai2008CarcinogenesisAM, title={Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics.}, author={Kohzoh Imai and Hiroyuki Yamamoto}, journal={Carcinogenesis}, year={2008}, volume={29 4}, pages={673-80} }