Carcinogen macromolecular adducts and their measurement.

  title={Carcinogen macromolecular adducts and their measurement.},
  author={Miriam C. Poirier and Regina M. Santella and Ainsley Weston},
  volume={21 3},
Damage to DNA induced by carcinogenic chemicals reflects exposure and is directly related to tumor formation, whereas modification of protein provides relatively precise dosimetry for stable adducts of proteins with a known half-life. Sophisticated methods for the detection and quantitation of DNA and protein adducts have been developed during the last approximately 25 years. For DNA adducts the most widely used methods include electrochemical detection, mass spectrometry, fluorescence and… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 49 extracted citations

Human Biomonitoring of DNA Adducts by Ion Trap Multistage Mass Spectrometry.

Current protocols in nucleic acid chemistry • 2016
View 4 Excerpts
Highly Influenced

Anthracyclines and ellipticines as DNA-damaging anticancer drugs: recent advances.

Pharmacology & therapeutics • 2012
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…