Carcinogen macromolecular adducts and their measurement.

@article{Poirier2000CarcinogenMA,
  title={Carcinogen macromolecular adducts and their measurement.},
  author={Miriam C. Poirier and Regina M. Santella and Ainsley Weston},
  journal={Carcinogenesis},
  year={2000},
  volume={21 3},
  pages={353-9}
}
Damage to DNA induced by carcinogenic chemicals reflects exposure and is directly related to tumor formation, whereas modification of protein provides relatively precise dosimetry for stable adducts of proteins with a known half-life. Sophisticated methods for the detection and quantitation of DNA and protein adducts have been developed during the last approximately 25 years. For DNA adducts the most widely used methods include electrochemical detection, mass spectrometry, fluorescence and… CONTINUE READING

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