Carcinogen-induced site-specific mutagenesis and genetic susceptibility in squamous cell carcinoma of the head and neck.

@article{Weber2002CarcinogeninducedSM,
  title={Carcinogen-induced site-specific mutagenesis and genetic susceptibility in squamous cell carcinoma of the head and neck.},
  author={Anette Weber and Andrea Tannapfel and Ch. Wittekind and Friedrich Bootz},
  journal={Onkologie},
  year={2002},
  volume={25 1},
  pages={8-13}
}
Tobacco and alcohol have been identified as the most important risk factors for squamous cell carcinomas of the head and neck (HNSCC). Especially for tobacco, some of the carcinogen-induced mutations that trigger transformation have been identified. Much attempt has been made to show a relationship between the mutations of growth regulatory genes, i.e. tumor suppressor- or oncogenes, and the exposure to specific exogeneous mutagens. One of the best examined genes - harboring the most DNA… CONTINUE READING