Carcinogen-induced frameshift mutagenesis in repetitive sequences.

@article{Lambert1992CarcinogeninducedFM,
  title={Carcinogen-induced frameshift mutagenesis in repetitive sequences.},
  author={I. Lambert and R. Napolitano and R. Fuchs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 4},
  pages={
          1310-4
        }
}
  • I. Lambert, R. Napolitano, R. Fuchs
  • Published 1992
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
    • We have constructed plasmids pS3G-1 and pSG4 that contain single acetylaminofluorene adducts within contiguous runs of three (5'-CCCG1G2G3-3') and four (5'-CG1GGG4T-3') guanine residues, respectively. In Escherichia coli, the frequency of induced -1 frameshift mutations was strongly dependent on the position of modification: pS3G-G3 was approximately 100-fold and 10-fold more mutagenic than pS3G-G1 and pS3G-G2, respectively; pSG4-G4 was approximately 600-fold more mutagenic than pSG4-G1… CONTINUE READING
    View on PubMed
    pnas.org
    98 Citations
    Background Citations
    22
    Methods Citations
    3
    98 Citations
    Citation Type

    Citation Type

    DNA sequence determinants of carcinogen-induced frameshift mutagenesis.
    • 36
    Sequence-dependent modulation of frameshift mutagenesis at NarI-derived mutation hot spots.
    • 37
    Complex frameshift mutations mediated by plasmid pKM101: mutational mechanisms deduced from 4-aminobiphenyl-induced mutation spectra in Salmonella.
    • 53
    • PDF
    A umuDC-independent SOS pathway for frameshift mutagenesis
    • 13
    Mutagenicity of a single 1-nitropyrene-DNA adduct N-(deoxyguanosin-8-yl)-1-aminopyrene in Escherichia coli located in a GGC sequence.
    • 7
    • PDF
    Mutagenesis at a site-specifically modified NarI sequence by acetylated and deacetylated aminofluorene adducts.
    • 17
    Mutagenicity and mutation spectra of 2-acetylaminofluorene at frameshift and base-substitution alleles in four DNA repair backgrounds of Salmonella.
    • 23
    The mutational specificity of l-nitroso-6-nitropyrene in the lacI gene of Escherichia coli strains deficient in nucleotide excision repair
    • 6
    • PDF
    Adducts formed by the food mutagen 2-amino-3-methylimidazo(4, 5-f ) quinoline induce frameshift mutations at hot spots through an SOS-independent pathway
    • 9
    Mutational spectrum induced in Saccharomyces cerevisiae by the carcinogen N-2-acetylaminofluorene
    • 6