Carcinogen-induced frameshift mutagenesis in repetitive sequences.

  title={Carcinogen-induced frameshift mutagenesis in repetitive sequences.},
  author={I. Lambert and R. Napolitano and R. Fuchs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={89 4},
  • I. Lambert, R. Napolitano, R. Fuchs
  • Published 1992
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • We have constructed plasmids pS3G-1 and pSG4 that contain single acetylaminofluorene adducts within contiguous runs of three (5'-CCCG1G2G3-3') and four (5'-CG1GGG4T-3') guanine residues, respectively. In Escherichia coli, the frequency of induced -1 frameshift mutations was strongly dependent on the position of modification: pS3G-G3 was approximately 100-fold and 10-fold more mutagenic than pS3G-G1 and pS3G-G2, respectively; pSG4-G4 was approximately 600-fold more mutagenic than pSG4-G1… CONTINUE READING
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