Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).

@article{Zheng2011CarcinoembryonicAC,
  title={Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4).},
  author={Jing Zheng and Katharine K. Miller and Tao Yang and Michael S. Hildebrand and A. Eliot Shearer and Adam P. DeLuca and Todd E. Scheetz and Jennifer Drummond and Steve E Scherer and P. Kevin Legan and Richard J Goodyear and Guy P Richardson and Mary Ann Cheatham and Richard J. H. Smith and Peter Dallos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 10},
  pages={4218-23}
}
We report on a secreted protein found in mammalian cochlear outer hair cells (OHC) that is a member of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) family of adhesion proteins. Ceacam16 mRNA is expressed in OHC, and its protein product localizes to the tips of the tallest stereocilia and the tectorial membrane (TM). This specific localization suggests a role in maintaining the integrity of the TM as well as in the connection between the OHC stereocilia and TM, a linkage… CONTINUE READING
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