Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells.

@article{Jessup2004CarcinoembryonicAI,
  title={Carcinoembryonic antigen induction of IL-10 and IL-6 inhibits hepatic ischemic/reperfusion injury to colorectal carcinoma cells.},
  author={John Milburn Jessup and Luciana M. Laguinge and Shuling Lin and Raed Samara and Kimberly Aufman and Paul Battle and Marilyn Frantz and Kirsten H. Edmiston and Philippe Thomas},
  journal={International journal of cancer},
  year={2004},
  volume={111 3},
  pages={
          332-7
        }
}
Tumor cells cause ischemia/reperfusion (I/R) injury as they arrest within the hepatic microvasculature with the production of nitric oxide (NO) and reactive oxygen species (ROS) that kill both host liver and implanting tumor cells. Carcinoembryonic antigen (CEA) both facilitates the survival of experimental metastasis to nude mouse liver by weakly metastatic human colorectal carcinomas (CRCs) and induces the release of the proinflammatory cytokine IL-6. We hypothesized that CEA also stimulates… CONTINUE READING

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