Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.

@article{Thomas2008CarcinoembryonicAA,
  title={Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow.},
  author={Susan N Thomas and Fei Zhu and Ronald L Schnaar and Christina S. Alves and Konstantinos Konstantopoulos},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 23},
  pages={
          15647-55
        }
}
Selectin-mediated adhesion of tumor cells to platelets, leukocytes, and endothelial cells may regulate their hematogenous dissemination in the microvasculature. We recently identified CD44 variant isoforms (CD44v) as functional P-, but not E- or L-, selectin ligands on colon carcinoma cells. Moreover, an approximately 180-kDa sialofucosylated glycoprotein(s) mediated selectin binding in CD44-knockdown cells. Using immunoaffinity chromatography and tandem mass spectrometry, we identify this… CONTINUE READING
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