Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity.

@article{Widemann1995CarboxypeptidaseG2RI,
  title={Carboxypeptidase-G2 rescue in a patient with high dose methotrexate-induced nephrotoxicity.},
  author={Brigitte C Widemann and M L Hetherington and Robert F. Murphy and Frank M Balis and Peter C. Adamson},
  journal={Cancer},
  year={1995},
  volume={76 3},
  pages={521-6}
}
BACKGROUND High dose methotrexate (HDMTX) induced renal failure is a medical emergency, as methotrexate (MTX) is primarily eliminated by renal excretion. High doses of leucovorin (LV) do not necessarily prevent toxicity in the presence of sustained elevated plasma MTX concentrations. The bacterial enzyme carboxypeptidase-G2 (CPDG2) hydrolyzes MTX into inactive metabolites and has been demonstrated to lower plasma MTX concentrations to nontoxic levels rapidly in the nonhuman primate after HDMTX… CONTINUE READING

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