Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.

  title={Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.},
  author={Kristin D. Jeffrey and Emilyn U. Alejandro and Dan S. Luciani and Tatyana B. Kalynyak and Xiaoke Hu and Hong Li and Yalin Lin and R. Reid Townsend and Kenneth S. Polonsky and James D Johnson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 24},
Obesity is a principal risk factor for type 2 diabetes, and elevated fatty acids reduce beta-cell function and survival. An unbiased proteomic screen was used to identify targets of palmitate in beta-cell death. The most significantly altered protein in both human islets and MIN6 beta-cells treated with palmitate was carboxypeptidase E (CPE). Palmitate reduced CPE protein levels within 2 h, preceding endoplasmic reticulum (ER) stress and cell death, by a mechanism involving CPE translocation to… CONTINUE READING
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