Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion.

@article{Dhanvantari2002CarboxypeptidaseEA,
  title={Carboxypeptidase E, a prohormone sorting receptor, is anchored to secretory granules via a C-terminal transmembrane insertion.},
  author={Savita Dhanvantari and Irina Arnaoutova and Chris R. Snell and Peter J. Steinbach and Kelli Hammond and Gregory A Caputo and Erwin London and Yoke Peng Loh},
  journal={Biochemistry},
  year={2002},
  volume={41 1},
  pages={52-60}
}
Carboxypeptidase E (CPE) is a sorting receptor that directs the prohormone pro-opiomelanocortin (POMC) to the regulated secretory pathway, and is also a prohormone processing enzyme in neuro/endocrine cells. It has been suggested that the 25 C-terminal amino acids are necessary for the binding of CPE to secretory granule membranes, but its orientation in the membrane is not known. In this study, we examined the structure and orientation of the membrane-binding domain at the C-terminus of CPE… CONTINUE READING

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