Carboxymethylation of Sperm Whale Metmyoglobin REACTIVITY OF THE ADJACENT

  • HISTIDINE RESIDUES
  • Published 2003

Abstract

The reactivities of the imidazole groups of histidyl residues in sperm whale myoglobin are being studied systematically to achieve a correlation with three-dimensional structure (1, 2). In the sequence between the Eand F-helices there occur 2 histidyl residues, EF4 and EF5, that can be isolated in the same tryptic peptide (3, 4).l It has been shown previously that treatment with bromoacetate before tryptic digestion yields a corresponding peptide differing only in that, on the average, 1 histidyl residue is changed to the dicarboxymethyl derivative (1). The present report establishes that the residue EF4 is reactive towards bromoacetate and EF5 is not.

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Cite this paper

@inproceedings{RESIDUES2003CarboxymethylationOS, title={Carboxymethylation of Sperm Whale Metmyoglobin REACTIVITY OF THE ADJACENT}, author={HISTIDINE RESIDUES}, year={2003} }