Carboxymethyl cellulose stimulates rabbit corneal epithelial wound healing.

  title={Carboxymethyl cellulose stimulates rabbit corneal epithelial wound healing.},
  author={Qian Garrett and Shunjiang Xu and Peter A. Simmons and Joseph G. Vehige and Ruo Zhong Xie and Ajay Sujit Kumar and Judith Louise Flanagan and Zhenjun Zhao and Mark Willcox},
  journal={Current eye research},
  volume={33 7},
PURPOSE Previously, we reported carboxymethyl cellulose (CMC) binding to human corneal epithelial cells and promoting corneal epithelial wound closure in vitro. Using an animal model, the efficacy of CMC in promoting corneal wound healing was examined. MATERIALS AND METHODS Following corneal epithelial wounding of NZ white rabbits, CMC (0.2% or 1.0%) or control vehicle (PBS) was administered topically (4 times daily for 3 days) to wounded and unwounded eyes with or without contact lens wear… CONTINUE READING