Carboxylesterase inhibitors.

@article{Hatfield2011CarboxylesteraseI,
  title={Carboxylesterase inhibitors.},
  author={Michael J. Hatfield and Philip M Potter},
  journal={Expert opinion on therapeutic patents},
  year={2011},
  volume={21 8},
  pages={
          1159-71
        }
}
INTRODUCTION Carboxylesterases play major roles in the hydrolysis of numerous therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety in these small molecules. However, the impact these enzymes may play on drug stability and pharmacokinetics is rarely considered prior to molecule development. Therefore, the application of selective inhibitors of this class of proteins may have utility in modulating the metabolism, distribution and toxicity of agents that… CONTINUE READING

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