Carboxylesterase inhibitors.

Abstract

INTRODUCTION Carboxylesterases play major roles in the hydrolysis of numerous therapeutically active compounds. This is, in part, due to the prevalence of the ester moiety in these small molecules. However, the impact these enzymes may play on drug stability and pharmacokinetics is rarely considered prior to molecule development. Therefore, the application… (More)
DOI: 10.1517/13543776.2011.586339

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