Carboxylated Superparamagnetic Iron Oxide Particles Label Cells Intracellularly Without Transfection Agents

@article{Mailaender2007CarboxylatedSI,
  title={Carboxylated Superparamagnetic Iron Oxide Particles Label Cells Intracellularly Without Transfection Agents},
  author={Volker Mailaender and Myriam Ricarda Lorenz and Verena Holzapfel and Anna Musyanovych and Karin M Fuchs and Markus Wiesneth and Paul Walther and Katharina Landfester and Hubert Schrezenmeier},
  journal={Molecular Imaging and Biology},
  year={2007},
  volume={10},
  pages={138-146}
}
Cell labeling by superparamagnetic iron oxide particles (SPIO) has emerged as a potentially powerful tool to monitor trafficking of transplanted cells by magnetic resonance tomography, e.g., in studies for tissue repair. However, intracellular labeling is mostly achieved by transfection agents not approved for clinical use. In this work, the feasibility and efficiency of labeling human mesenchymal stem cells (MSC) and HeLa cells with two commercially available SPIOs (Resovist® and Feridex… CONTINUE READING

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