Carboxyl-terminal Domain of p27Kip1 Activates CDC2*

@article{ren1997CarboxylterminalDO,
  title={Carboxyl-terminal Domain of p27Kip1 Activates CDC2*},
  author={Aykut {\"U}ren and Judit Jakus and Jaime Font de Mora and Andrew Yeudall and Eugenio Santos and Silvio J Gutkind and Mohammad A. Heidaran},
  journal={The Journal of Biological Chemistry},
  year={1997},
  volume={272},
  pages={21669 - 21672}
}
A variant form of p27 was unexpectedly detected in a synchronized culture of NIH3T3 cells treated with serum. The expression levels of this form of p27 which lacked its amino (NH2)-terminal region reached maximum during G2/M phase. Since the appearance of the NH2-terminal truncated form of p27 coincided with increased expression of Cdc2, we hypothesized that p27 may play a role in regulating Cdc2 catalytic activity. To test this hypothesis, wild type p27, as well as the amino-terminal (Np27… 

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