Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates.

  title={Carboxyfullerene neuroprotection postinjury in Parkinsonian nonhuman primates.},
  author={Laura L. Dugan and Linlin Tian and Kevin L. Quick and Josh I Hardt and Morvarid K Karimi and Chris L Brown and Susan K. Loftin and Hugh Flores and Stephen M. Moerlein and John Polich and Samer D Tabbal and Jonathan W. Mink and Joel S. Perlmutter},
  journal={Annals of neurology},
  volume={76 3},
OBJECTIVE We evaluated the efficacy of the potent antioxidant C3 to salvage nigrostriatal neuronal function after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure in nonhuman primates. C3 is a first-in-class functionalized water-soluble fullerene that reduces oxygen radical species associated with neurodegeneration in in vitro studies. However, C3 has not been evaluated as a neuroprotective agent in a Parkinson model in vivo. METHODS Macaque fascicularis monkeys were used in a… CONTINUE READING
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Parkinson’s disease: genetics and pathogenesis

  • JM Shulman, PL De Jager, MB. Feany
  • Annu Rev Pathol
  • 2011
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