Carboplatin-based Nanomedicine to Enhance the Anticancer Effect in SK-NEP-1 WilmsꞌTumor Cells

  title={Carboplatin-based Nanomedicine to Enhance the Anticancer Effect in SK-NEP-1 WilmsꞌTumor Cells},
  author={Ming Ming and Z. Ma and Yong-tao Xu and Feng-yin Sun and Xin-hai Cui},
  journal={Iranian Journal of Pharmaceutical Research : IJPR},
  pages={1305 - 1311}
  • Ming Ming, Z. Ma, +2 authors Xin-hai Cui
  • Published 2017
  • Chemistry, Medicine
  • Iranian Journal of Pharmaceutical Research : IJPR
  • Wilms tumor (WT) is the most common pediatric malignant primary renal tumor. Carboplatin (CRB), a platinum compound is widely used in the treatment of multiple cancers including ovarian, lung, head and neck, and wilm’s tumor. However, lower uptake of CRB in cancer cells and toxicity concerns in healthy cells often limited its clinical outcome. The aim of this study was to investigate the antitumor effect of CRB on SK-NEP-1 wilm’s cancer cells. Earlier, CRB was formulated in nanoparticulate… CONTINUE READING


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