Carbonylation of oxyhemoglobin solution (HbO2→ HbCO) using a membrane oxygenator

Abstract

 In the purification process of hemoglobin (Hb) from red blood cells, we stabilized Hb as carbonylhemoglobin (HbCO) against pasteurization at 60°C. In this study, the process of carbonylation (HbO2→ HbCO) was tested with a membrane oxygenator (CX-II08; membrane area, 0.8 m2; maximum circulation rate, 1.2 l/min) under the conditions of a solution flow rate… (More)
DOI: 10.1007/s100470200018

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