Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease.

@article{Smith1995CarbonylrelatedPM,
  title={Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease.},
  author={Mark A. Smith and Maria Rudnicka-Nawrot and Peggy L. Richey and Darja Praprotnik and Paul Mulvihill and Carol Ann Miller and Lawrence M. Sayre and George Perry},
  journal={Journal of neurochemistry},
  year={1995},
  volume={64 6},
  pages={2660-6}
}
We present the first evidence for carbonyl-related posttranslational modifications of neurofilaments in the neurofibrillary pathology of Alzheimer's disease (AD). Two distinct monoclonal antibodies that consistently labeled neurofibrillary tangles (NFTs), neuropil threads, and granulovacuolar degeneration in sections of AD tissue also labeled the neurofilaments within axons of the white matter following modification by reducing sugars, glutaraldehyde, formaldehyde, or malondialdehyde. The… CONTINUE READING

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