Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol.

@article{BreyerPfaff2004CarbonylRO,
  title={Carbonyl reduction of naltrexone and dolasetron by oxidoreductases isolated from human liver cytosol.},
  author={Ursula Breyer-Pfaff and Karl Nill},
  journal={The Journal of pharmacy and pharmacology},
  year={2004},
  volume={56 12},
  pages={1601-6}
}
The opioid receptor antagonist naltrexone and the antiemetic 5-HT(3) receptor antagonist dolasetron are ketonic drugs that are efficiently reduced to their corresponding alcohols in-vivo. These experiments aimed at characterizing the role in these reactions of individual oxidoreductases present in human liver cytosol. Aldo-keto reductases (AKRs) and carbonyl reductase (CR, EC 1.1.1.184) purified from human liver cytosol were incubated with varying substrate concentrations and 6beta-naltrexol or… CONTINUE READING
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