Carbonic anhydrases of anaerobic microbes.

  title={Carbonic anhydrases of anaerobic microbes.},
  author={James G. Ferry},
  journal={Bioorganic & medicinal chemistry},
  volume={21 6},
Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to bicarbonate and are abundantly distributed in prokaryotes and eukaryotes. There are five classes (α,β,γ,δ,ζ) with no significant sequence or structural identity among them, a remarkable example of convergent evolution. The β and γ classes predominate in anaerobic microbes, living without O2, that comprise a substantial portion of the living protoplasm on Earth. Anaerobes reside in the lower intestinal tract of… CONTINUE READING