Carbonic anhydrases--an overview.

  title={Carbonic anhydrases--an overview.},
  author={Claudiu T. Supuran},
  journal={Current pharmaceutical design},
  volume={14 7},
Carbonic anhydrases (CAs, EC are widespread metalloenzymes all over the phylogenetic tree, with at least 4 distinct gene families encoding for them. At least 16 different alpha-CA isoforms were isolated in mammals, where these enzymes play crucial physiological roles. Representatives of the beta-delta-CA family are highly abundant in plants, diatoms, eubacteria and archaea. These enzymes are efficient catalysts for the reversible hydration of carbon dioxide to bicarbonate, but at least… CONTINUE READING
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