Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.

@article{Stiti2008CarbonicAI,
  title={Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II.},
  author={Maamar Stiti and Alessandro Cecchi and M Younis Rami and Mohamed Abdaoui and V{\'e}ronique Barragan-Montero and Andrea Scozzafava and Yannick Guari and Jean-Yves Winum and Claudiu T. Supuran},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 48},
  pages={
          16130-1
        }
}
An approach for the synthesis of carbonic anhydrase (CA, EC 4.2.1.1) inhibitor coated gold nanoparticles is reported. This nanomaterial selectively inhibited the tumor-associated isoform CA IX overexpressed in hypoxic cancers over the ubiquitous, cytosolic housekeeping isozymes CA I and II and was membrane impermeant. As CA IX has an extracellular active site, the new nanomaterial which is confined to the extracellular space may be useful for imaging and treatment of hypoxic tumors. 
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