Carbonic anhydrase inhibition with natural products: novel chemotypes and inhibition mechanisms

@article{Supuran2010CarbonicAI,
  title={Carbonic anhydrase inhibition with natural products: novel chemotypes and inhibition mechanisms},
  author={Claudiu T. Supuran},
  journal={Molecular Diversity},
  year={2010},
  volume={15},
  pages={305-316}
}
Five genetically distinct classes of carbonic anhydrases (CAs, EC 4.2.1.1) are present in organisms all over the phylogenetic tree (α-, β-, γ-, δ-, and ζ-families). These metalloenzymes catalyze CO2 hydration to bicarbonate and protons. Inhibition of α-CAs from vertebrates, including humans, with sulfonamides was exploited clinically for decades for various classes of diuretics and systemically acting antiglaucoma agents, whereas newer inhibitors are used as topically acting antiglaucoma drugs… CONTINUE READING
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