Carbonic anhydrase in the normal rat stomach and duodenum and after treatment with omeprazole and ranitidine.

@article{Lnnerholm1989CarbonicAI,
  title={Carbonic anhydrase in the normal rat stomach and duodenum and after treatment with omeprazole and ranitidine.},
  author={Gudmar L{\"o}nnerholm and Lars F. Knutson and Per J. Wistrand and Gunnar Flemstr{\"o}m},
  journal={Acta physiologica Scandinavica},
  year={1989},
  volume={136 2},
  pages={
          253-62
        }
}
A low pH in the lumen of the stomach and duodenum stimulates gastroduodenal mucosal secretion of bicarbonate, particularly in the duodenum. Long-term deprivation of this acid stimulus might affect the ability of the mucosa to secrete bicarbonate, with a consequent decrease in mucosal protection against the acid. This could occur by 'down-regulation' of carbonic anhydrase (CA) activity in the bicarbonate-transporting cells. Levels of CA activity and amounts of CA isoenzymes in rat gastric and… CONTINUE READING

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