Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.

Abstract

A novel class of tight binding carbonic anhydrase (CA) activators was designed by using histamine and histidine as lead molecules. Carnosine (beta-Ala-His) derivatives were synthesized by reaction of appropriately derivatized beta-alanines with imidazole/carboxy-protected histidine in the presence of carbodiimides, followed by removal of the various… (More)

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Cite this paper

@article{Scozzafava2002CarbonicAA, title={Carbonic anhydrase activators: high affinity isozymes I, II, and IV activators, incorporating a beta-alanyl-histidine scaffold.}, author={Andrea Scozzafava and Claudiu T. Supuran}, journal={Journal of medicinal chemistry}, year={2002}, volume={45 2}, pages={284-91} }