Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.

Abstract

The mitochondrial isozymes of human carbonic anhydrase (hCA, EC 4.2.1.1), hCA VA and hCA VB, were investigated for activation with a series of amino acids and amines. D-His, L-DOPA, histamine, dopamine, and 4-(2-aminoethyl)morpholine were excellent hCA VA activators, with KAs in the range of 10-130 nM. Good hCA VB activating effects were identified for L… (More)

Topics

Cite this paper

@article{Vullo2007CarbonicAA, title={Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.}, author={Daniela Vullo and Isao Nishimori and Alessio Innocenti and Andrea Scozzafava and Claudiu T. Supuran}, journal={Bioorganic & medicinal chemistry letters}, year={2007}, volume={17 5}, pages={1336-40} }