Carbonic anhydrase XIV in the normal and hypertrophic myocardium.

  title={Carbonic anhydrase XIV in the normal and hypertrophic myocardium.},
  author={Lorena A. Vargas and Bernardo V. Alvarez},
  journal={Journal of molecular and cellular cardiology},
  volume={52 3},
Two AE3 transcripts, full-length (AE3fl) and cardiac (AE3c) are expressed in the heart. AE3 catalyzes electroneutral Cl(-)/HCO(3)(-) exchange across cardiomyocyte sarcolemma. AE proteins associate with carbonic anhydrases (CA), including CAII and CAIV, forming a HCO(3)(-) transport metabolon (BTM), increasing HCO(3)(-) fluxes and regulating cardiomyocytes pH. CAXIV, which is also expressed in the heart's sarcolemma, is a transmembrane enzyme with an extracellular catalytic domain. Herein, AE3… CONTINUE READING