Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.

@article{Svastov2012CarbonicAI,
  title={Carbonic anhydrase IX interacts with bicarbonate transporters in lamellipodia and increases cell migration via its catalytic domain.},
  author={Eliska Svastov{\'a} and Wojciech Witarski and Lucia Csaderova and Ivan Ko{\vs}{\'i}k and Lucia Skvarkov{\'a} and Alzbeta Hul{\'i}kov{\'a} and Miriam Zaťovi{\vc}ov{\'a} and Monika Bar{\'a}thov{\'a} and Juraj Kop{\'a}cek and Jarom{\'i}r Pastorek and Silvia Pastorekov{\'a}},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 5},
  pages={3392-402}
}
Carbonic anhydrase IX (CA IX) is a hypoxia-induced cell surface enzyme expressed in solid tumors, and functionally involved in acidification of extracellular pH and destabilization of intercellular contacts. Since both extracellular acidosis and reduced cell adhesion facilitate invasion and metastasis, we investigated the role of CA IX in cell migration, which promotes the metastatic cascade. As demonstrated here, ectopically expressed CA IX increases scattering, wound healing and transwell… CONTINUE READING