Carbonic anhydrase IV on brain capillary endothelial cells: a marker associated with the blood-brain barrier.

@article{Ghandour1992CarbonicAI,
  title={Carbonic anhydrase IV on brain capillary endothelial cells: a marker associated with the blood-brain barrier.},
  author={Mustapha Ghandour and O. Keith Langley and Xin Liang Zhu and Abdul Rais Abdul Waheed and William S. Sly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 15},
  pages={
          6823-7
        }
}
Carbonic anhydrase (CA) activity plays an important role in controlling cerebrospinal fluid production and also influences neuroexcitation and susceptibility to seizures. Until recently, CA II was the only CA demonstrated in brain. Its distribution is limited to the epithelial cells of the choroid plexus and to the myelin-forming cells, the oligodendrocytes. In this report, we present immunoblots, using an antibody raised to CA IV from rat lung, that show that CA IV is also present in rat and… CONTINUE READING
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