Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.

@article{Fleming1995CarbonicAI,
  title={Carbonic anhydrase IV expression in rat and human gastrointestinal tract regional, cellular, and subcellular localization.},
  author={Robert E. Fleming and Seppo Parkkila and Anna Kaisa Parkkila and Hannu Rajaniemi and Abdul Rais Abdul Waheed and William S. Sly},
  journal={The Journal of clinical investigation},
  year={1995},
  volume={96 6},
  pages={
          2907-13
        }
}
Carbonic anhydrase IV (CA IV) is a glycosylphosphatidylinositol-linked isozyme previously identified on the surface of renal tubular epithelium and certain populations of vascular endothelium. This report identifies the regional, cellular, and subcellular localization of CA IV in the rat gut. Northern blot and RT-PCR analyses demonstrated little CA IV expression in stomach or proximal small intestine, but abundant expression in distal small and large intestine. In contrast, CA II mRNA was… CONTINUE READING
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