Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+.

@article{Lehenkari1998CarbonicAI,
  title={Carbonic anhydrase II plays a major role in osteoclast differentiation and bone resorption by effecting the steady state intracellular pH and Ca2+.},
  author={Petri Lehenkari and Teuvo A. Hentunen and Tiina K Laitala-Leinonen and Juha Tuukkanen and H. Kalervo V{\"a}{\"a}n{\"a}nen},
  journal={Experimental cell research},
  year={1998},
  volume={242 1},
  pages={128-37}
}
Carbonic anhydrase II (CA II) expression in characteristic for the early stage of osteoclast differentiation. To study how CA II, which is crucial in proton generation in mature osteoclasts, influences the osteoclast differentiation process we performed rat bone marrow cultures. In this model, acetazolamide, a specific CA inhibitor, decreased the 1,25 (OH)2D3-induced formation of multinucleated tartrate-resistant acid phosphatase (TRAP)-positive cells, in a dose-dependent manner. We then… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 36 extracted citations

Thymol inhibits RANKL-induced osteoclastogenesis in RAW264.7 and BMM cells and LPS-induced bone loss in mice.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2018

Similar Papers

Loading similar papers…