Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells.

@article{Lin2008CarbonicA2,
  title={Carbonic anhydrase 2-like a and 15a are involved in acid-base regulation and Na+ uptake in zebrafish H+-ATPase-rich cells.},
  author={Tzung-Yi Lin and Bo-Kai Liao and J L Horng and Jia-Jiun Yan and C. -F. Hsiao and Pung-Pung Hwang},
  journal={American journal of physiology. Cell physiology},
  year={2008},
  volume={294 5},
  pages={C1250-60}
}
H(+)-ATPase-rich (HR) cells in zebrafish gills/skin were found to carry out Na+ uptake and acid-base regulation through a mechanism similar to that which occurs in mammalian proximal tubular cells. However, the roles of carbonic anhydrases (CAs) in this mechanism in zebrafish HR cells are still unclear. The present study used a functional genomic approach to identify 20 CA isoforms in zebrafish. By screening with whole mount in situ hybridization, only zca2-like a and zca15a were found to be… CONTINUE READING
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