Carbonic anhydrase: chemistry, physiology, and inhibition.

  title={Carbonic anhydrase: chemistry, physiology, and inhibition.},
  author={Thomas H. Maren},
  journal={Physiological reviews},
  volume={47 4},
  • T. Maren
  • Published 1 October 1967
  • Chemistry, Medicine
  • Physiological reviews
Carbonic anhydrase VII regulates dendritic spine morphology and density via actin filament bundling
This work identified amino acids unique to CAVII that are required for direct actin interactions, promoting actin filament bundling and spine targeting, and demonstrates highly distinct subcellular expression patterns of CAII and CAVII, and a novel, structural role of CAVII. Expand
Studies on the mechanism of swelling-induced lysosomal alkalinization in vascular smooth muscle cells
Osmotic swelling of vascular smooth muscle cells leads to lysosomal alkalinization, presumably in large part through activation of a hydrogen ion leak. Expand
Changes in Chemoreflex Characteristics Following Acute Carbonic Anhydrase Inhibition in Humans a Rest
In conclusion, acute CA inhibition enhanced the central chemosensitivity to CO2 but diminished the peripheral chemos sensitivity. Expand
Physiological Functioning of Carbonic Anhydrase in the Hydrothermal Vent Tubeworm Riftia Pachyptila.
R. pachyptila demonstrates very effective acquisition of inorganic carbon from the environment, thereby providing the symbionts with large amounts ofCO2, made possible by three factors: extremely effective pH regulation, a large external pool of CO2, and high levels of carbonic anhydrase. Expand
A physiological measure of carbonic anhydrase in müller cells
The activity of Müller cell carbonic anhydrase may help to buffer extracellular CO2 variations in the retina, and was characterized in freshly dissociated Müller cells of the salamander retina. Expand
The functional significance of plasma-accessible carbonic anhydrase for cardiovascular oxygen transport in teleosts
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Molecules in pain and sex: a developing story
Determining whether pain signalling is sexually dimorphic in humans and addressing the sex bias in pain research will increase the translational relevance of preclinical findings and advance the understanding of chronic pain in women. Expand
Transcriptional and Post-translational Regulation of Cytosolic Carbonic Anhydrase in Rainbow Trout (Oncorhynchus mykiss) and Zebrafish (Danio rerio)
The enzyme carbonic anhydrase (CA) contributes to multiple physiological processes by catalysing the reversible hydration of carbon dioxide. However, regulation of CA activity in response toExpand
Diuretics with carbonic anhydrase inhibitory action: a patent and literature review (2005 – 2013)
These effects seem to be due to the potent inhibition of such drugs against CA isoforms present in kidneys and blood vessels, which explain both the blood pressure lowering effects as well as organ-protective activity of the drugs. Expand
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Purification and proper&a of human erythrocytt carbonic anhydrase
  • J. Biol. C&n
  • 1966
The meaturem art of rate of aqueous 0. STEPHENSON, AND A. M. WILD. Studies in outflow with iodide
  • Invest. Ophthalmol
  • 1962
Action vcntilatorc de l’acttazolamide. ‘II. Gradient alv&olo-art&iel de la pression partielle de gaz carbonique chez le chicn soumis B me ventilation constante
  • Rco. Franc. Etudes Clin. Sol
  • 1959
The carbonic anhydrase inhibitor in serum
  • V. H. Booth
  • Chemistry, Medicine
  • The Journal of physiology
  • 1938
An active inhibitor of carbonic anhydrase found in the sera of pig and other mammals, was briefly described in a recent note, but much of the force of this suggestion was lost on finding that the inhibitor is not present in the blood of man. Expand
Effcctl, of pCoI, acetazolamide, and ouabain on volume and composition of choroid-plcxua fluid
  • J. Physiol. (London)
  • 1965
anhydrase activity and the distribution of Diamox in HILTON. Effects of maleic acid on renal function. the rabbit
  • eye. Am. J. OphthaZmoZ
  • 1955
Secretion of sodium by the resting, stimulated, and inhibited canine gastric mucosa.
Effect of acetazolamide and magnesium therapy on erythrocyte survival in sickle-cell anaemia and sickle-cell-haemoglobin-C disease
It is clear that acetazolamide and magnesium have no significant therapeutic effect on the haematological picture of patients with sickle-cell disease, but closely supervised use of magnesium might be valuable in diminishing the effects of thrombotic incidents. Expand
Relation of potassium concentration in choroidplexus fluid to that in plasma.
The studies to be reported are concerned with the movement of K+ from blood to choroids-plexus fluid and with the regulation of its concentration in the choroid-plexu fluid. Expand
Action of acetazolamide on the secretion of hydrobromic acid by the gastric muco4)8
  • AGto P&iol. Lu&oum
  • 1964