Carbonate and carbamate derivatives of 4-demethylpenclomedine as novel anticancer agents

  title={Carbonate and carbamate derivatives of 4-demethylpenclomedine as novel anticancer agents},
  author={L. Morgan and R. Struck and W. Waud and Blaise Leblanc and A. H. Rodgers and B. S. Jursic},
  journal={Cancer Chemotherapy and Pharmacology},
  pages={829 - 835}
  • L. Morgan, R. Struck, +3 authors B. S. Jursic
  • Published 2009
  • Chemistry, Medicine
  • Cancer Chemotherapy and Pharmacology
  • PurposeThe purpose of this investigation was to synthesize a series of carbonate and carbamate derivatives of 4-demethylpenclomedine (DM-PEN), the major plasma non-toxic metabolite of penclomedine (PEN) seen in patients. DM-PEN has been observed to be an active antitumor agent in mouse human xenograft tumor models and non-neurotoxic in a rat model, however, activity in intracranially implanted human glioma xenograft models have not been reported. The major goal was to identify derivatives that… CONTINUE READING
    18 Citations
    NeuroPharmacology: As Applied to Designing New Chemotherapeutic Agents
    • 1
    • PDF
    Chapter 15 A Rational for Novel Anti-NeuroOncology Drugs
    • PDF
    A Rational for Novel Anti-NeuroOncology Drugs
    • 2
    • PDF
    The big picture on nanomedicine: the state of investigational and approved nanomedicine products.
    • 605


    Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolite of penclomedine
    • 5
    Thiolo-, thiono- and dithiocarbonate and thiocarbamate derivatives of demethylpenclomedine as novel anticancer agents
    • 3
    Preclinical antitumor activity of an alpha-picoline derivative, penclomedine (NSC 338720), on human and murine tumors.
    • 25
    Tissue and tumor distribution of C-penclomedine in rats.
    • S. O'Reilly, N. Hartman, +6 authors E. Rowinsky
    • Biology, Medicine
    • Clinical cancer research : an official journal of the American Association for Cancer Research
    • 1996
    • 8
    • PDF
    Murine and human in vivo penclomedine metabolism.
    • 11
    • PDF
    The alkylating agent penclomedine induces degeneration of purkinje cells in the rat cerebellum
    • 7