Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-beta 1.

@article{Delaney1994CarbonTS,
  title={Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-beta 1.},
  author={Bobbi Delaney and Stephen C. Strom and Sheila Collins and Norbert E. Kaminski},
  journal={Toxicology and applied pharmacology},
  year={1994},
  volume={126 1},
  pages={98-107}
}
In vivo exposure of B6C3F1 mice to the hepatotoxic chlorinated hydrocarbon, CCl4, suppresses T-cell-dependent humoral immune responses to sRBC. In the present studies, separation-crossover-reconstitution experiments with spleen cell subpopulations isolated from vehicle and CCl4-treated mice (500 mg/kg/day for 7 days) indicate that T-cells are the primary immunologic cell-type altered following CCl4 exposure. Despite suppression of T-cell activity, Con A-activated spleen cell supernatants from… CONTINUE READING