Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats.

@article{Ozturk2003CarbonTN,
  title={Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats.},
  author={Feral Ozturk and M. Cigdem Ucar and Ismail Cetin Ozturk and Nigar Vardi and Kadir Batçioğlu},
  journal={Urology},
  year={2003},
  volume={62 2},
  pages={353-6}
}
OBJECTIVES To observe the changes in the antioxidative defense enzymes and to detect the alterations of renal microscopy after carbon tetrachloride (CCl4) administration in rats and to investigate the possible protective effects of betaine against CCl4-induced renal damage. METHODS Thirty-two adult Sprague-Dawley rats were divided into four groups as follows: control group, betaine group, CCl4 group, and CCl4 + betaine group. CCl4 was given subcutaneously at 1 mL/kg. In the CCl4 + betaine… CONTINUE READING

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