Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants.

@article{Sheweita2001CarbonTC,
  title={Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants.},
  author={Salah A Sheweita and M A El-Gabar and M Bastawy},
  journal={Toxicology},
  year={2001},
  volume={169 2},
  pages={83-92}
}
The cytochrome P-450 enzymes are responsible for the oxidation of xenobiotic chemicals including drugs, pesticides, and carcinogens. These enzymes include cytochrome P450, cytochrome b(5), arylhydrocarbon (benzo[a]pyrene) hydroxylase (AHH), NADPH-cytochrome C reductase and dimethylnitrosamine N-demethylase I (DMN-dI). Changes in the activities of the above mentioned enzymes were studied in the liver microsomes of rats treated with antioxidants (ascorbic acid (AA), DL-a-tocopherol (vitamin E, VE… CONTINUE READING