Carbon nanotube-quenched fluorescent oligonucleotides: probes that fluoresce upon hybridization.

@article{Yang2008CarbonNF,
  title={Carbon nanotube-quenched fluorescent oligonucleotides: probes that fluoresce upon hybridization.},
  author={Ronghua Yang and Jianyu Jin and Yan Juan Chen and Na Shao and Huaizhi Kang and Zeyu Xiao and Zhiwen Tang and Yanrong Wu and Zhi Zhu and Weihong Tan},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 26},
  pages={8351-8}
}
We report an effective, novel self-assembled single-wall carbon nanotube (SWNT) complex with an oligonucleotide and demonstrate its feasibility in recognizing and detecting specific DNA sequences in a single step in a homogeneous solution. The key component of this complex is the hairpin-structured fluorescent oligonucleotide that allows the SWNT to function as both a "nanoscaffold" for the oligonucleotide and a "nanoquencher" of the fluorophore. Given this functionality, this carbon nanotube… CONTINUE READING