Carbon monoxide treatment reduces microglial activation in the ischemic rat retina

@article{Ulbrich2016CarbonMT,
  title={Carbon monoxide treatment reduces microglial activation in the ischemic rat retina},
  author={Felix Ulbrich and Ulrich Goebel and Daniel B{\"o}hringer and Petar Charalambous and Wolf Alexander Lagr{\`e}ze and Julia Biermann},
  journal={Graefe's Archive for Clinical and Experimental Ophthalmology},
  year={2016},
  volume={254},
  pages={1967-1976}
}
Ischemia and reperfusion (I/R) injury damages retinal neurons. Retinal injury is accompanied by activation of microglia, which scavenge the dead or dying neurons, but increasing evidence now indicates that amoeboid-shaped microglia cells activated in the brain after ischemia have neurotoxic and damaging properties in their own right. A previous study showed that postconditioning with carbon monoxide (CO) protects retinal ganglion cells (RGCs) after I/R through anti-apoptotic and anti… CONTINUE READING