Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function.

@article{Ghio2008CarbonMR,
  title={Carbon monoxide reversibly alters iron homeostasis and respiratory epithelial cell function.},
  author={Andrew J Ghio and Jacqueline G. Stonehuerner and Lisa A. Dailey and Judy H. Richards and Michael D Madden and Zhongping Deng and N H Nguyen and Kimberly D. Callaghan and Funmei Yang and Claude A. Piantadosi},
  journal={American journal of respiratory cell and molecular biology},
  year={2008},
  volume={38 6},
  pages={715-23}
}
The dissociation of iron from heme is a major factor in iron metabolism and the cellular concentrations of the metal correlate with heme degradation. We tested the hypotheses that (1) exposure to a product of heme catabolism, carbon monoxide (CO), alters iron homeostasis in the lung and in cultured respiratory epithelial cells; (2) this response includes both decreased uptake and increased release of cell metal; and (3) the effects of CO on cell function track changes in metal homeostasis. In… CONTINUE READING
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